Global Advanced Research Journals! Welcome::::::GARJERR>Prashant and Amitı: An innovative approach to prolong gastric retention:- “Floating microspheres of cimetidine hydrochloride”

The purpose of this research work was to developed and optimize a controlled-release multiunit floating system of a freely water soluble drugs such as (CHCL). Cimetidine is a histamine H₂-receptor antagonist that inhibits the production of acid in the stomach. It is largely used in the treatment of heartburn and peptic ulcers Oral delivery of the water soluble drug is so far the most preferable and ease route of drug delivery due to the ease of administration, patient compliance and flexibility in the formulations, but immediate release to site-specific delivery, oral dosage form has really progressed as compaired to novel dosage forms. Various attempts have been made to develop gastro-retentive delivery systems. For example floating, swelling, mucoadhesive, and high-density system. These systems have more flexibility in dosage design than conventional dosage form Cimetidine-HCL lipid microspheres were prepared by the melt granulation technique and evaluated for in vitro floating and drug release. Ethyl cellulose, methylcellulose, and hydroxypropyl methylcellulose were evaluated as release rate modifiers.

Keywords: Floating Microspheres, H2 Receptor, Tagamet HB or Tagamet HB200