A pioneering approach to enhance Dissolution and Bioavailability of multiple drugs in a single Dosage form “speedy disintegrating tablet of Cefpodoxime Proxetil and Potassium Clavulanate”

Khemariya P¹*, Rawal C², Mavila A², Rai P³

¹Sr. Research Scientist- Formulation

²Human BioScience Limited.

³Aligharh Collage of Pharmacy Allogharh UP

*Corresponding author Email: dr.p.khemariya@gmail.com

Accepted 31 July, 2012

Abstract

The demand of fast dissolving tablets has been growing during the last decade especially for geriatric and pediatric patients because of difficulties in administration. So this research was to formulation and evaluation of fast dissolving tablets with combination of two drugs namely Cefpodoxime Proxetil and Potassium Clavulanate. These tablets were prepared by using mannitol, microcrystalline cellulose etc. as filler, crospovidone, croscarmillose, SSG as super disintegrants and also used sweetener like sucralose , flavor as peppermint or orange or in combination of both, one glidant i.e. aerosil and one or combination of lubricants and antiadherents in different concentration. Total ten formations and one control batch were prepared and evaluated for hardness, friability, weight variation, content uniformity, wetting time, water absorption ratio, disintegration time and invitro drug release (all tests were performed as mentioned in The Pharmacopoeia IP,BP or USP). Optimized formulation that was DP-07 compared with control formulation for disintegration time and % drug release. The stability studies were performed as per ICH guidelines. The Optimized formulation DP-07 shown no significant variations for the tablets parameters and it was stable for the specified time period. It was concluded the FDT for Cefpodoxime Proxetil and Potassium Clavulanate can be formulated for emergency treatment of bacterial infection.

Keywords: FDT, Super Disintegrants, Stability Study, ICH.