|
January 2013 Vol. 2
Issue 1
Other viewing option
Abstract
• Full
text
•Reprint
(PDF) (164 KB)
Search Pubmed for articles by:
Ahmadu BU
Zira FB
Other links:
PubMed Citation
Related articles in PubMed
Indexed by: EyeSource
 |
|
Global Advanced Research Journal
of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
January 2013 Vol. 2(1), pp.
001-005
Copyright © 2013 Global Advanced
Research Journals
Full Length Research Paper
|
Does placental malaria infection impairs the passage
of measles antibodies from mothers to their newborn
infants?
Baba Usman
Ahmadu1,
Rabasa Adamu Ibrahim2,
Bukbuk David3,
Musa Alhaji Bukar4,
Bashir Faruk2,
Chama Rejoice2, Abdulrahim Halima2
and
Fate Bala Zira5
1Department
of Paediatrics, Federal Medical Centre, Yola,
Adamawa, Nigeria.
2Department
of Paediatrics, University of Maiduguri Teaching
Hospital, Borno, Nigeria.
3Department
of Immunology, University of Maiduguri Teaching
Hospital, Borno, Nigeria.
4Department
of Histopathology, University of Maiduguri Teaching
Hospital, Borno, Nigeria.
5Department
of health services Federal Polytechnic Mubi Adamawa
state Nigeria.
*Corresponding Author
E-mail:
ahmadu4u2003@yahoo.com; Phone: +2348033668948
Accepted 08 January, 2013
|
|
Abstract |
|
Infants are protected from measles by maternal
measles antibodies (MMA). The level of these
antibodies in infants at birth depends on maternal
levels and the extent of placental transfer, which
can be impaired by placental malaria. The efficiency
of transplacental transfer of MMA was assessed in
relation to placental malaria in Maiduguri. A
hospital based cross-sectional descriptive study was
carried out on 104 mother-infant pairs. Subjects
were selected using systematic random sampling and
tested for MMA at delivery. Placental tissues for
the diagnosis of placental malaria infection were
also obtained. Correlation coefficient was used to
investigate the relationship of MMA of mother-infant
pairs and Student t test was used to test for
significance of means. Fifty eighty (55.8 %) newborn
infants had mothers diagnosed with placental
malaria. Of these, nine (8.7 %) newborn infants had
unprotective levels of MMA. Correlation of MMA in
mother-infant pairs was significant (p = 0.003).
Overall mean (SD) MMA of newborn infants was 208.81
(75.46), 95 CI (194.13 – 223.48). While mean (SD)
MMA of newborn infants of mothers with placental
malaria was 194.60 (83.42), 95 CI (172.67 – 216.54),
those whose mothers were uninfected was 226.72
(60.28), 95 CI (208.82 – 244.61), and comparison of
these means was significant (p = 0.030). Placental
malaria infection was associated with reduction of
MMA in our newborn infants.
Keywords:
Placental malaria, maternal measles antibodies,
newborn infants, Maiduguri.
|
| |
|
