Burden of Infection Caused by Methicillin-Resistant Staphylococcus aureus in Bangladesh: a Systematic Review

M. Abdullah Yusuf¹, Professor KM Shahidul Islam², AKM Shamsuzzaman³, Iftikhar Ahmed⁴, AFM Arshedi Sattar⁵

¹Assistant Professor, Department of Microbiology, National Institute of Neurosciences and Hospital, Dhaka.

²Professor  and Head, Department of Microbiology, Dhaka Medical College, Dhaka

³Chief Scientific Officer, Department of Virology, Institute of Epidemiology, Disease Control and Research, Dhaka

⁴Professor and Head, Department of Microbiology, Enam Medical College, Dhaka

⁵Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka

Corresponding Author’s Email: ayusuf75@yahoo.com; 

Tel: +8801817565830

Accepted 02 December, 2013

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is becoming an important public-health problem worldwide as well as in Bangladesh. Objective: The aim of this present review is to see the clinical burden of MRSA in the health care setting and well as the community of Bangladesh. Methodology: Studies conducted on humans in Bangladesh concerning MRSA colonization or infection were identified through computerized literature searches using free text searching, Google Scholar, Banglajol, MEDLINE (National Library of Medicine Bethesda MD) and EMBASE and by reviewing the references of the retrieved articles. Studies were excluded that did not provide appropriate data on the prevalence of MRSA. The search was restricted to full articles published from January 2000 to December 2013. Only English language was applied. Result: Of 125 studies identified during systematic review, 19 studies met the criteria for analysis. The level of evidence and freedom from bias of these studies were generally low. The isolation rate of MRSA among all culture isolates ranged from 4.8-78.7%. All studies had been reported from the hospital setting and only two studies had been reported from community settings though the CDC definition was not followed either study. Conclusion: MRSA have created a huge clinical burden in the hospital settings as well as in the community of Bangladesh.

Keywords: Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, CA-MRSA, HA-MRSA, antibiotic therapy, evolution, systematic review.