Rhazya stricta plant is considered an important medical species used as a herbal drug in traditional medicine, and have always played a major role in the treatment of human and animal diseases. Over 100 alkaloids have been isolated, characterized and identified from R. stricta leaves, stems, roots. The aim of this research was a histological study to investigate the effect of different doses of Rhazya srticta extract administrated orally to albino mice for 15, 30 and 45 days on the hepatic and renal tissues and cells of these experimental animals. The tissues were examined under three types of stain, Haematoxylin and eosin, Masson trichrome staining and the immunohistochemictry method. The results indicated the safety of administering the extract up to 30 days in spite of the little changes that were observed in the hepatic tissues of the treated animals. But extending the administration period up to 45 days caused serious variations in the tissue structure, hepatocytes got swollen with cytoplasmic vacuolization and granulation, accompanied by presence of thick collagen fibers and little activity of the specific hepatocyte antigen (OCHIE5). 

Keywords: Rhazya srticta- traditional medicine  histological structure- liver – kidney- albino mice