The present study was planned to examine the effect of the venom of the yellow scorpion Leurus quinquestriatus (Arachnoida) venom on the histological structure of the liver and kidney of albino mice. Ten albino mice with the same age (45 days)and approximately the same the same body weight (25±5 gm) were used . The venom was obtained from L.quinquestrianus which was collected from Al-Khomra area near Jeddah City, by means of an electric stimulation . The mice were subjected to intercellular injections with the scorpion venom with a dose of 0.03 mg/km , and the animals were left 6 hours before being dissected . The animals were anaethetised with diethyl ether ,dissected and small parts of the liver and kidney were removed. Michrotmic sections were made and three materials were used to stain the sections , each specialized in certain characteristics. The venom caused remarkable histological alterations in the liver and kidney tissue structure, like nuclear margination, nuclear pyknosis, karyolysis, cell swelling, cellular necrosis, cellular damage, and inactivation of the antigen marking the endothelial clls (CD34).

Keywords: Yellow scorpion - venom - histological structure- liver – kidney- albino mice.