Sedation with Dexmedetomidine or Propofol for Carotid Endarterectomy, a Randomized Clinical Trial

Dr. Mesut Öterkuş¹, Dr. Ruslan Abdullayev¹*, Dr. Ömer Burak Küçükebe¹, Dr. Şefika Türkan Kudsioğlu², Dr. Sezer Karabulut² and

Prof. Dr. Zuhal Aykaç²

¹Adiyaman University Research and Educational Hospital, Anesthesiology and Reanimation

²Prof. Dr. Siyami Ersek Research and Educational Hospital, Department of Anesthesiology and Reanimation.

*Corresponding Author E-mail: ruslan_jnr@hotmail.com; Tel:+905063010833

Accepted 02 September, 2014

Abstract

Sedation of the patient during operation under regional anesthesia improves the quality of anesthesia and is sometimes mandatory. Many sedative agents like benzodiazepines, narcotic analgesics, propofol, dexmedetomidine have been used for sedation. We aimed to compare sedative and hemodynamic effects of dexmedetomidine and propofol given for sedation to patients undergoing operation under regional anesthesia. After the approval of Local Ethics Committee 28 patients of ASA 1-3 physical status, aged 50-80 years old, scheduled for carotid endarterectomy operation, were enrolled for the study. Patients were randomly allocated into two groups, each containing 14 patients. 0.5 mg/kg/h propofol infusion in the first group (Group P) and 0.2 μg/kg/h dexmedetomidine infusion in the second group (Group D) was given. Systolic, mean, diastolic arterial pressures (SAP, MAP, DAP), heart rates (HR) and Ramsey Sedation Scores (RSS) of the patients were recorded. MAP, DAP and SpO₂ values were significantly different between the groups, but this had no clinical significance. RSS scores achieved targeted values, but two groups revealed no significant difference. Both propofol and dexmedetomidine can be safely used for sedation in patients undergoing carotid endarterectomy under regional anesthesia, if the appropriate monitoring conditions are provided.

Keywords: Dexmedetomidine, propofol, carotid endarterectomy, sedation.