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October 2014 Vol. 3 Issue
10
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Reza-Lopez SA
Levario-Carrillo M
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Global Advanced Research Journal
of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
October 2014 Vol. 3(10), pp.
315-321
Copyright © 2014 Global Advanced
Research Journals
Full Length Research Paper
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Expression of glucose transporters in placenta from
macrosomic infants
Sandra Alicia Reza-López Ph.D1, Blanca
Estela Sánchez-Ramírez Ph.D2, Daniela
Sarahí Gutiérrez-Torres M.Sc2, Mariela
Rodríguez-Salinas1, Martha Grisell
Ortega-Valerio1, Dora Virginia
Chávez-Corral M.D1 and Margarita
Levario-Carrillo, Ph.D1*
1Facultad
de Medicina, Universidad Autónoma de Chihuahua.
Circuito Universitario, Campus II, C.P. 31109,
Chihuahua, Chih., México.
2Programa
de Maestría en Ciencias en Biotecnología, Facultad
de Ciencias Químicas, Universidad Autónoma de
Chihuahua. Circuito Universitario, Campus II, C.P.
31109, Chihuahua, Chih., México
*Corresponding Author
Email: mlevarioc@uach.mx;
Phone: +52 (614) 439-1500 Ext. 3572; Fax +52 (614)
238-6036
Accepted 17 October, 2014
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Abstract |
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Maternal glucose status and placental transport are
related to macrosomia in pregnancies complicated
with diabetes mellitus. However, there is little
information on the placental expression of glucose
transporters in non-complicated pregnancies. The
objective of this study was to compare the
expression glucose transporters GLUT1 and GLUT3 in
placenta from macrosomic and normal weight newborns.
Information on maternal factors was obtained from
clinical records. Protein expression of GLUT1 and
GLUT3 glucose transporters was determined by
immunohistochemistry in archived term placenta
samples of singleton, non-diabetic pregnancies, from
macrosomic (>4000g) and normal weight
newborns, matched for gestational age (±1week) and
gender (n=25 pairs) for a case-control study.
Macrosomia was more frequent in newborns from women
with pregestational overweight (body mass index ≥25
kg/m2, p=0.046) or with glucose concentration ≥85
mg/dL (p=0.01). Placentas in the highest tertile of
GLUT3 expression had 5 times the chance of being
from macrosomic newborns compared to controls
(p<0.05). This association remained significant
after adjusting for other maternal factors. Protein
expression of GLUT1 was not different between
groups. Term placentas from macrosomic newborns from
uncomplicated pregnancies show increased protein
expression of GLUT3 but not GLUT1.
Keywords:
Macrosomic, placenta, glucose, GLUT, birth weight
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