Rhazya strictadecne plant has been considered as medical plant for treating many human and animal diseases. In this study the leaf extract of the plant was orally administered at a dose of 3.75 mg/km as a pretreatment to albino mice against toxic injuries of the venom of the yellow scorpion Leurius quinquestriatus. The durations of the pretreatments were 15, 30, 45 days. The examination was carried out on the histological and anatomical structure of the liver and kidney as it is known that envenomation usually causes many tissue alterations and injuries. The study showed that in spite of the adverse effects and alterations that had occurred on the mice hepatic and renal tissues due to the injected venom, the R. stricta leaf extract has caused partial improvement on the histological structure of the liver and kidney depending on the duration of the pretreatmen. The improvement increased gradually with increase in the pretreatment period. After 45 days of pretreatment most of the hepatic cells look normal as elongated tapes, and the renal tissue showed normal appearance of the glomerulus, the proximal and distal tubules and the nuclei, and also the thick and thin limbs on Henle loop and the collecting tubules are all normal. The collagen fibers were seen very thick in the liver tissue, and its presence was also observed in the kidney tissue after 45 days pretreatment. Extending the pretreatment period up to 45 days also induced very strong activity of the antigen (CD34) in the kidney tissue similar to that of the control. We suggest more work in this field.

Keywords: Histochemical Studies, Rhzya stricta, Scorpion Venam.